Ageing is the main risk factor for Alzheimer’s disease and aluminium accumulates in human brain tissue with ageing.
Environmental or occupational exposure to aluminium results in higher levels of aluminium in human brain tissue and an early onset form of sporadic Alzheimer’s disease.
The genetic predispositions which are used to define familial or early-onset Alzheimer’s disease also predispose individuals to higher levels of brain aluminium at a much younger age.
Aluminium is accepted as a known neurotoxin, for example being the cause of dialysis encephalopathy, and its accumulation in human brain tissue at any age can only contribute to any ongoing disease state or toxicity.
Yes I am aware aluminium has been recognised as a neuro toxin, along with many other metals and metalloids. This paper specifically looks at the heavy metal overload of iron as a direct consequence of exposure to arsine gas and arsenic species. So far I have not come across the potential for prion misfolding as per arsenic but there may well be examples.
Fascinating, thank you. What do you mean by "gain of function mechanism" or was this just a direct quote from the article? If you are right where is the arsenic coming from? Might there be a connection with Seb's insight into excess cremations?
We suspect that arsenic triggers a gain-of-function type effect in the mutations it creates in proteins. The misfolding can lead to duplications of aberrant proteins and spreading of diseased cells. We are still reviewing the cremation data. Unlikely to have much to do with GoF
🚂 Hi there, Caroline! Thanks so much for participating in the Terrain Train! I’m writing to encourage everyone involved to share this information on and off Substack as much as possible throughout the month of October. Tremendous gratitude for all that you're doing to raise awareness in the health truth movement! https://solluckman.substack.com/p/calling-all-those-questioning-germ
Ageing is the main risk factor for Alzheimer’s disease and aluminium accumulates in human brain tissue with ageing.
Environmental or occupational exposure to aluminium results in higher levels of aluminium in human brain tissue and an early onset form of sporadic Alzheimer’s disease.
The genetic predispositions which are used to define familial or early-onset Alzheimer’s disease also predispose individuals to higher levels of brain aluminium at a much younger age.
Aluminium is accepted as a known neurotoxin, for example being the cause of dialysis encephalopathy, and its accumulation in human brain tissue at any age can only contribute to any ongoing disease state or toxicity.
Yes I am aware aluminium has been recognised as a neuro toxin, along with many other metals and metalloids. This paper specifically looks at the heavy metal overload of iron as a direct consequence of exposure to arsine gas and arsenic species. So far I have not come across the potential for prion misfolding as per arsenic but there may well be examples.
Fascinating, thank you. What do you mean by "gain of function mechanism" or was this just a direct quote from the article? If you are right where is the arsenic coming from? Might there be a connection with Seb's insight into excess cremations?
We suspect that arsenic triggers a gain-of-function type effect in the mutations it creates in proteins. The misfolding can lead to duplications of aberrant proteins and spreading of diseased cells. We are still reviewing the cremation data. Unlikely to have much to do with GoF
🚂 Hi there, Caroline! Thanks so much for participating in the Terrain Train! I’m writing to encourage everyone involved to share this information on and off Substack as much as possible throughout the month of October. Tremendous gratitude for all that you're doing to raise awareness in the health truth movement! https://solluckman.substack.com/p/calling-all-those-questioning-germ